Pharmaceutical production sites are most of the time built around several clean rooms, from A to D grades.
These specific « rooms » have to be controlled frequently in terms of surface and airborne microbiological contamination (ISO 14698, GMP…).
In this study, the airborne contamination of 22 rooms (B, C and D grades) has been measured and compared. The sampling has been done with 2 different methods : the referent one, the impaction on agar plates (+incubation for 72h) and the cyclonic sampling method, based on a patented technology transferring airborne particles onto a liquid collection media (+ solid phase cytometry analysis).
● 33 measures with each sampling method into 22 rooms of the production site.
● A better representativeness of the airborne contamination in the controlled environments with the couple Coriolis®μ + ScanRDI® is observed, especially for D grade room which are the most contaminated rooms and thus give the most exploitable results.