Dynamics of Pneumocystis Carinii air shedding during experimental Pneumocystosis - Bertin Instruments

    Biomédical et santé

    Dynamics of Pneumocystis Carinii air shedding during experimental Pneumocystosis

    Sources: Dept. of Parasitology-Mycology, Paris Diderot University and St Louis Hospital; Center of infection and Immunity of Lille, Univ. of Lille, France


    The genus Pneumocystis designates opportunistic extracellular fungal species infecting a wide range of mammals, including humans. In immunocompromised patients, the airborne-transmitted Pneumocystis jirovecii (human-derived Pneumocystis) is responsible for a sever interstitial alveolar lung disease, Pneumocystis pneumonia (PcP), which is fatal without specific treatment. Most of knowledge of the pathogenesis and transmission of Pneumocystis is gained from experimental animals models [1].
    To better understand the diffusion of Pneumocystis in the environment, airborne shedding of Pneumocystis carinii in the surrounding air of experimentally infected rats was quantified by means of a real-time polymerase chain reaction assay, in parallel with the kinetics of P. carinii loads in their lungs [1].


    P.carinii DNA was detected in the air 1 week after infection and increased until 4-5 weeks after infection before stabilizing. A significant correlation was shown between lung burdens and the corresponding airborne levels, suggesting the possibility of estimating the fungal lung involvement through quantification of Pneumocystis in the exhaled air [1].
    This study [1] describe for the first time the kinetics of the air excretion of P.carnii during the course of pneumocystosis.


    pneumocystis carinii


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